INFLUENCE OF THYROID
STATUS ON SERUM IMMUNOREACTIVE LEPTIN LEVELS
Yu Fang, Lin Hanhua, Wei Hong.
Department of Pediatrics, Tongji Hospital, Tongji
Medical collage, Huazhong University of Science and Technology, Wuhan
430032, China
Objective: The
aim of this study was to assess the influence of hypothyroidism and
hyperthyroidism on serum leptin level.
Methods: The
serum T3 、T4 、TSH and leptin concentration and body mass index
(BMI) were measured in 15 children with hypothyroidism, 10 children with
hyperthyroidism before and after successful treatment and 10 normal control
subjects.
Results: Serum
leptin concentration were correlated significantly (P<0.05) with BMI in
the hypothyroid(r=0.49), thy hyperthyroid (r=0.46) and normal(r=0.63). Even
through age、sex and BMI were similar
in all groups, serum leptin levels in the hypothyroid children（0.64±0.39）were significantly (P<0.05) low than in the
hyperthyroid（2.51±1.5） and normal groups（2.06±1.07）.Leptin levels in the hyperthyroid were similar
before （2.51±1.5）and after（1.32±0.74）, and were
similar to the control value（2.06±1.07）.
Conclusion:
These results indicate that thyroid hormone plays a role in the appropriate
secretion of leptin in human.