PERIPHERAL BLOOD
LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-8 AND TUMOR NECROSIS FACTOR-ALPHA
IN NEONATAL HIE AND ITS INFLUENCE ON CEREBRAL ARTERIESHEMODYNAMICS
Liu J, Di YF, Cao HY
Beijing Yanhua Hospital, Beijing, China
Objective: To assess the
influence of birth asphyxia and HIE on interleukin-6(IL-6), Interleukin-8
(IL-8) and tumor necrosis factor-alpha (TNF-α) peripheral blood
levels in asphyxiated neonates and to analyze the influence of cytokines on
cerebral arterieshemodynamics.
Methods: Perlpheral blood
samples were obtained at time of 1 day, 3 day and 7 day after birth from 80
full-term neonates for measuring serum levels of IL-6,IL-8 and TNF-α by using
immunoassays, the neonates were classified into two groups according to the
presence or absence of birth asphyxia and HIE. The cerebral arteries
hemodynamics were determined by using the color Doppler ultrasonography.
Results: (1)Birth asphyxia
was associated with a decrease in IL-6 (52.6±24.5) vs (80.2±29.4)ng/L(p<0.01)
and in IL-8 (0.47±0.13 )vs( 0.68±0.16) μg/L(p<0.01) and an increase in TNF-α(1.18±0.31) vs (0.91±0.30) μg/L(p<0.01)).(2)
The resistance index(RI) negatively correlated with IL-6(r=-0.61,p<0.01),
and positively correlated with IL-8 and TNF-α(r=0.80,0.72,respectively
,p<0.01). Conclusion Birth
asphyxia and HIE were associated with elevated TNF-αcord blood levels
in full-term neonates while with asphyxia was associated with decreased
IL-6 levels and IL-8. Cytokines have a significant influence on cerebral
arterieshemodynamics.