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CLINICAL AND PATHOLOGIC STUDY IN PEDIATRIC COMPLICATED HEPATOPATHY

Huai YW¹, Zhu QR¹, Wang DM¹, Duan SC¹, Zhai WR², Hu XQ²

¹ Children’s Hospital, Shanghai Medical University, Shanghai, China

² Anatiomicopathological Teaching and Research Dept., Shanghai Medical University, Shanghai, China

Objective: To study the clinical and pathologic features of pediatric complicated hepatopathy.

Methods: Light microscope, electron microscope and immunohistochemical method (PAP, LSAB) were employed to study the liver tissue speciments from needle biopsy of 94 cases of pediatric hepatopathy. Clinical analysis was done simultaneously.

Results: 12 kinds of liver diseases were conformed by pathologic study. Viral hepatitis ranked (67% in all), in every different stages of hepatitis B, it was comparatively extensive of the lesion of the nuclease and cell organs in liver and the pathologic diagnosis was more serious than clinical. The pathologic features of HCV were liver cell fatty changes and bile ducts damage. Fat-storing cells played an important role in the liver fibrosis. In addition to the viral hepatitis, there were glycogen storage disease, fatty liver, congenital hepatic cirrhosis and Reye’s syndrome, etc.

Conclusion: Pediatric hepatopathy with clinical complicated features and different pathologic change can be induced by many kinds of diseases.

Key words: hepatopathy, hepatic biopsy, pathology