0024
RESEARCH ON
THE CHANGES AND SIGNIFICANCE OF ADENYLIC ACID METABOLISM IN THE HEARTS OF
SIRS RATS LI Wei*, LIU
Chunfeng, YUAN Zhuang, et al. Department of
Pediatrics, The 2nd Clinical Hospital, China Medical
University*, Shenyang 110003, China Objective: In order to
recognize the metabolic changes of energy in SIRS and prevent SIRS from
developing into MODS, the changes of myocardial cellular structure and
metabolic changes of energy were searched in SIRS rats. Methods:
(1) High-dose endotoxin (LPS) induced the model of SIRS then
it was determined that whether the rectal temperature, heart rate,
respiratory rate, TNF-a in blood, the amount of leukocyte and its
classification had some alternations in SIRS rats. (2) The content of ATP, ADP, AMP in
hearts of SIRS rats was measured with the method of HPLC. (3) The
pathological changes in SIRS rats were viewed with electron microscope. Results: (1) The content of ATP ADP and AMP in myocardium
cells show
a significant reduction in SIRS groups (P<0.05). (2) Under the electron microscope, the
mitochondria in myocardium cells of SIRS rats increase in quantity and have
disorders in structure. The myocardial fibers are edematous. Conclusions: Microcirculatory
dysfunction, disorders between oxygen delivery (DO2) and oxygen consumption
(VO2), impaired energy metabolism, and mitochondrial
dysfunction have all played important roles in
the development of systemic inflammatory response syndrome.