0026

ANALYSIS OF AA AND DHA IN THE PLASMA AND ERYTHROCYTE OF NEWBORN INFANTS

Zhang Weili¹, Wu Shengmei¹, Qian Jihong¹, Yang Hongwei², Shen Yuehua³, Zhu Hui¹

1.Shanghai Xin Hua Hospital, Shanghai Second Medical University

2.Shanghai First Maternity and Infant Hospital

3.Shanghai International Maternity and Infant Hospital

Objective: In order to know the contents of arachidonic acid (AA) and docosahexaenoic acid (DHA) in the blood of newborn infants.

Methods: The contents of AA and DHA in the plasma and red blood cells in 50 newborns of one day and fifteen days of age were analyzed by capillary gas chromatography.

Results: The concentrations of AA and DHA in the plasma were 19.2+4.8mg/dl (10.7±2.2%) and 7.4±2.7mg/dl (4.1±1.2%) respectively in the first day and were decreased to 14.5±4.5mg/dl (6.2±1.5%) (p<0.01) and 6.7±2.8md/dl (2.9±1.0%) (p<0.01) in the fifteenth day after birth. On the contrary, the total fatty acid (TFA) content in the plasma was increased significantly from 183.6±50.7mg/dl in the first day to 235.6±48.3mg/dl in the fifteenth day (p<0.01). The concentrations of AA and DHA in the erythrocytes were 17.7±2.0% and 6.3±1.6% in one day of age and were decreased to 15.3±2.6% (p<0.05) and 5.2±1.5% (p<0.01) in fifteen days of age, but the TFA content in the erythrocyte didn't change within the fifteen days after birth.

Conclusions: The concentrations of AA and DHA in the erythrocytes were higher than that in the plasma in newborn infants. The concentrations of AA and DHA both in plasma and erythrocytes were decreased after birth, but the concentrations of AA and DHA in erythrocytes were decreased more slowly than that in plasma.