0029

pulmonary venous flow spectrum to Evaluate ventricular function in children with renal hypertension

Qiu Y, Sheng X-G, Ling R-L, Song H

First Hospital, Shantou University Medical College, Shantou, China

Objective: To study the change and relationship between pulmonary venous flow (PVF) spectrum and left ventricular (LV) function in children with renal hypertension(RH), as well as to evaluate the influence of enalapril to left ventricular function.

Methods: 25 normal children as control group and 24 cases with RH (RH group) were studied. The LV function (EF, E, A, E/A), PVF spectrum (S, D, AR, S/D), RVPEP/AT, AT/RVET were measured transthoracically with HP-5050 color Doppler echocardiography.

Results: Significant differences were found in D wave (39.32±8.26 cm/s vs. 52.37±7.81cm/s, P<0.001), AR (31.57±3.72cm/s vs. 24.33±4.35cm/s, P<0.01)、S/D (1.30±0.37 vs.0.89±0.40, P<0.05) between RH group and control group, also in E (0.62±0.12m/s vs. 0.76±0.10m/s, P<0.05)、A (0.63±0.11m/s vs. 0.46±0.09m/s, P <0.01)、E/A（0.98±0.30 vs. 1.65±0.32, P<0.01）. There were significant changes in all the above parameters between before and after the enalapril therapy in RH group except for S and EF. RH group existed significant differences in RVPEP/AT (1.13±0.17 vs. 0.87±0.15, P<0.05) and AT/RVET (0.29±0.05 vs. 0.36±0.08, P<0.05) compared with control group. There were significant relativity between D or AR and AT/RVET (respectivelyγ=0.82, γ=-0.85).

Conclusion: PVF spectrum and mitral valve flow spectrum might be used to evaluate LV diastolic function of RH children. The changes of D, AR and AT/RVET could sensitively reflect RV after-load. And enalapril could improve the LV diastolic function of RH children.