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THE RELATIONSHIP BETWEEN GROWTH HORMONE BINDING PROTEIN, INSULIN WITH BODY FAT AND GROWTH IN CHILDREN WITH SIMPLE OBESITY

Du Minlian, Su Yunyun

First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou, China

OBJECTIVE: To observe on the relationship between body-fat with growth hormone binding protein (GHBP) and insulin (Ins) in order to clear the relationship between alterations of somatotropin axis with growth and metabolism in obese children.

METHODS: Subjects were 119 cases of healthy pupils, 71 obese, and 49 non-obese as control. To measure the height, weight, waist circumference (WC), hip circumference (HC) and to measure the abdominal subcutaneous fat(SFAT) by ultrasound. To measure the fasting serum GHBP, Ins and glucose, and Ins and glucose at 30 minutes after glucose loading. Calculated height SD score (HtSDS), derived parameters of INS(insulin sub-curve area, insulin releasing index and insulin sensitive index) were used as analyzed parameters.

RESULTS: 1) The HtSDS, WC, HC, SFAT, GHBP and derived parameters of insulin in obese group were all more than control group significantly (p<0.001), but not WC/HC ration. 2) HtSDS in obese group was more than control group (p<0.01). A positive significant relationship between GHBP and HtSDS was found (p<0.01) 3) Derived parameters of Ins and GHBP related separately with BMI, WC, HC and SFAT significantly. 4) A significant relationship between GHBP and derived parameters of Ins was also found. 5) BMI, WC, HC and SFAT had strong relationship with each other.

CONCLUSION: Increasing in serum level of GHBP and Ins related with excessive accumulation of body-fat. GHBP links up closely with hyperinsulinemia. Increasing of GHBP refracts duble compensation of somatotropin axis forgrowth and metabolism in obese children. GHBP is a significant biochemical mark for body-fat as well as insulin. The ultrasound is a reliable mean for measuring subcutaneous fat. The signification of using WC, HC as dependent parameter was better than the WC/HC ration for referring body-fat situation in obese child.

KEY WORDS: GHBP, insulin, fat, growth, obese child