0035
THE RELATIONSHIP BETWEEN GROWTH HORMONE BINDING
PROTEIN, INSULIN WITH BODY FAT AND GROWTH IN CHILDREN WITH SIMPLE OBESITY Du Minlian, Su Yunyun First Affiliated Hospital of Sun Yat-sen
University of Medical Sciences, Guangzhou, China OBJECTIVE: To observe on the
relationship between body-fat with growth hormone binding protein (GHBP)
and insulin (Ins) in order to clear the relationship between alterations of
somatotropin axis with growth and metabolism in obese children. METHODS: Subjects were 119 cases
of healthy pupils, 71 obese, and 49 non-obese as control. To measure the
height, weight, waist circumference (WC), hip circumference (HC) and to
measure the abdominal subcutaneous fat(SFAT) by ultrasound. To measure the
fasting serum GHBP, Ins and glucose, and Ins and glucose at 30 minutes
after glucose loading. Calculated height SD score (HtSDS), derived
parameters of INS(insulin sub-curve area, insulin releasing index and
insulin sensitive index) were used as analyzed parameters. RESULTS: 1) The HtSDS, WC, HC,
SFAT, GHBP and derived parameters of insulin in obese group were all more
than control group significantly (p<0.001), but not WC/HC ration. 2)
HtSDS in obese group was more than control group (p<0.01). A positive
significant relationship between GHBP and HtSDS was found (p<0.01) 3)
Derived parameters of Ins and GHBP related separately with BMI, WC, HC and
SFAT significantly. 4) A significant relationship between GHBP and derived
parameters of Ins was also found. 5) BMI, WC, HC and SFAT had strong
relationship with each other. CONCLUSION: Increasing in serum
level of GHBP and Ins related with excessive accumulation of body-fat. GHBP
links up closely with hyperinsulinemia. Increasing of GHBP refracts duble
compensation of somatotropin axis forgrowth and metabolism in obese
children. GHBP is a significant biochemical mark for body-fat as well as
insulin. The ultrasound is a reliable mean for measuring subcutaneous fat.
The signification of using WC, HC as dependent parameter was better than
the WC/HC ration for referring body-fat situation in obese child. KEY WORDS: GHBP, insulin, fat,
growth, obese child