0040
THE OBSERVATION OF A
LONG-TERM EFFECTS OF SODIUM SELENITE AND VITAMIN E ON TREATMENT OF
NEPHROTIC SYNDROME IN CHILDREN Jin M,
Huang BR, Zhang XN First People's
Hospital, Lanzhou, China Objective: To evaluate the long-term effects of sodium
selenite and vitamin E (VE) on treatment of nephrotic syndrom (NS) in
children. Methods:
The
patients in two groups were treated by glucocorticoid based on routine
therapy.37 cases of NS were treated with sodium selenite at a dose of
0.5mg/day for one week, then a dose of 0.5mg/week for 6 months, and which
were treated with VE at a dose of 100mg three times daily for 6 months. 20
cases that were not treated by sodium selenite and VE served as control
group. Then serum seleniun(Se)、plasma glutathione
pexoxidase (GSH-Px),plasma malondialdehyde (MDA) and serum immunoglobulins
were observed before and after treatment. During 1.6~7.5 years of follow-up study, the therapeutic effects in two groups
were being observed. Results: After treatment, Se and GSH-Px levels in
the herapeutic group were significantly higher than the control
(p<0.01), and MDA level of therapeutic group was decreased obviously
(p<0.05), and serum immunoglobulins returned to normal level. Complete
remission rate was 83.38% and 55%, recurrent rate was 10.71% and 54.54%
compared the threapeutic group with control group, there were significantly
difference between two groups (p<0.01; p<0.001). Conclusion: After sodium selenite
and VE treatment, complete remission rate was enhanced, and recurrent rate
was decreased. The result indicated this may help to explain the partial
mechanisms of proteinuria and hypoproteinmia with NS. The treatments of
sodium selenite and VE (antioxidation) may be effective for NS in children.
It is suggested that the reduction of Se may be one of causes of an easy
infection and recurrence with NS