0040

THE OBSERVATION OF A LONG-TERM EFFECTS OF SODIUM SELENITE AND VITAMIN E ON TREATMENT OF NEPHROTIC SYNDROME IN CHILDREN

Jin M, Huang BR, Zhang XN

First People's Hospital, Lanzhou, China

 

Objective: To evaluate the long-term effects of sodium selenite and vitamin E (VE) on treatment of nephrotic syndrom (NS) in children.

Methods: The patients in two groups were treated by glucocorticoid based on routine therapy.37 cases of NS were treated with sodium selenite at a dose of 0.5mg/day for one week, then a dose of 0.5mg/week for 6 months, and which were treated with VE at a dose of 100mg three times daily for 6 months. 20 cases that were not treated by sodium selenite and VE served as control group. Then serum seleniun(Se)plasma glutathione pexoxidase (GSH-Px),plasma malondialdehyde (MDA) and serum immunoglobulins were observed before and after treatment. During 1.67.5 years of follow-up study, the therapeutic effects in two groups were being observed.

Results: After treatment, Se and GSH-Px levels in the herapeutic group were significantly higher than the control (p<0.01), and MDA level of therapeutic group was decreased obviously (p<0.05), and serum immunoglobulins returned to normal level. Complete remission rate was 83.38% and 55%, recurrent rate was 10.71% and 54.54% compared the threapeutic group with control group, there were significantly difference between two groups (p<0.01; p<0.001).

Conclusion: After sodium selenite and VE treatment, complete remission rate was enhanced, and recurrent rate was decreased. The result indicated this may help to explain the partial mechanisms of proteinuria and hypoproteinmia with NS. The treatments of sodium selenite and VE (antioxidation) may be effective for NS in children. It is suggested that the reduction of Se may be one of causes of an easy infection and recurrence with NS