0041

THYROID FUNCTION OF NEPHROTIC SYNDROME IN CHILDREN

Zhang Yuwen, Meng Qun, Meng Fanying et al.

Beijing Children’s Hospital, Beijing 100045, China

Objective: To know thyroid function of massive proteinuria stage and remission duration of pediatric idiopathic nephroticc syndrome (PINS).

Methods: We collected serum and 24h urine sample of 38 cases with PINS hospitalized and OPD from Feb. 1998 to April. 2000 and measured T3, T4, TSH, FT3, FT4, rT3, TBG respectively by radioimmunoassay. We compared above data before therapy with that after steroid-therapy then we analyzed above measured results by statistics (SPSS) and combining serum albumin profile and 24h-protein excretion in urine with the clinical pattern of IPNS.

Results: The serum measured results in 38 with PINS showed that above indexes of thyroid function were abnormalities of different degree in 31 and returned to normal levels in 26 (86.7%) after remission; only 5 cases who had massive proteinuria for more than two months discharged still with heavy proteinuria and with hypothyroidism. There were significant positive correlation between serum albumin and serum T4, FT4 levels and that significant negative correlation between serum albumin and serum TSH, urinary protein excretion amount and T4, FT3 output in 24h urine before treatment.There was significant negative correlation between protein excretion amount in 24h urine and serum T4 and that significant positive correlation between protein excretion in 24h urine and serum TSH before treatment.

Conclusion: In our study, there were 31cases(81.6%) with IPNS who had low level serum T3, T4, FT3, FT4, rT3, TBG during massive proteinuria but the most of above low indexes were temporary and associated with their loss from massive proteinuria so that we suggested that short time thyroxin replacement therapy to patients with IPNS who had massive proteinuria for more than two months will be helpful for remission.