0050

STUDY ON THE PHARYNGEAL CARRIAGE OF HAEMOPHILUS INFLUENZAE

Zhang H-W, Ye L-Y, Chen X-M, Huang L-H, Lai G-X, Lin M-Y.

Department of Pediatrics, Fuzhou East Hospital, Fuzhou, China

Objective: To investigate the characteristics of the pharyngeal carriage of Haemophilus influenzae (Hi) in healthy preschool children.

Methods: Research subjects include two representative kindergartens in Fuzhou. Obtained from pharynx in healthy children by the method of oropharyngeal swab in the first month of each season, samples totals 2053 specimens and were cultured on Improved Columbia Chocolated Agar.

Results: The average positive rate of Hi is 19.63% of the year. There is a statistically significant difference in the detection rate and the biotype distribution of the isolated strains of Hi in different seasons. The highest carriage rate happened in winter. There is a higher drug-resistance rate to antibiotic in common use in the isolated strains.

Conclusions: The pharyngeal carriage of Hi is closely related to different season patterns. The study reveals that vaccine can be used to prevent this disease before winter of highest Hi level. This study provides an important piece of information for the treatment of invasive disease of Hi.