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CHARACTERISTICS OF NEONATAL JAUNDICE IN GUANGXI, CHINA

Liu Yi, Liu Younan, Zhong Danni

1st Affiliated Hospital, Guangxi Medical University, Nanning, China

 

Objective: 13 nationalities and 50 million people are living in southern China - Guangxi. We have studied the characteristics of neonatal jaundice in Guangxi.

Methods: The ethnic disturbance and normal serum bilirubine (SB) value were studied in 227 term neonates. The causes of hyperbilirubinemia and relationship of dose-effect in phototherapy and use of intravenous gamma globulin were studied. Results: 227 cases of normal term neonates, 23.8% of Zhuang (壮) nationality, 5.7% of Yao (瑶) nationality, others are Han (汉) nationality. The peak SB value is 180 ± 45 μmol/L at 4-5 days postnatally, 23% is above than 220 μmol/L, 11% is above 256 μmol/L. In our area the primary cause of neonatal hyperbilirubinemia is G-6-PD deficiency (38%), the second is ABO hemolysis disease of newborn (ABO HDN) (12.8%), other cases could not be determined. Appearances of jaundice in the cases of G-6-PD deficiency are varied and the jaundice persist longer times. The phototherapy apparatus is made by local factory. The effect on decreasing SB level is about 10mg / dl after 48 hours of phototherapy. Relationship of dose-effect in phototherapy existed. Both in ABO HDN and G-6-PD deficiency we use IVIG plus phototheraphy and the jaundice decreased more rapidly than control group.

Conclusion: Guangxi Zhuang Autonomous Region is a multi-nationality region in China. The characteristics of neonatal jaundice are (1) a high percentage of normal term neonates and their SB level is more than 12-15 mg/dl (2) G-6-PD deficiency is the primary cause of neonatal hyperbilirubinemia, another cause is ABO HDN. (3) phototherapy apparatus which is made by local factory could decrease the SB about 10mg/dl after 48 hours of phototherapy. (4) Therapy of neonatal jaundice with  phototherapy plus IVIG is effective in both ABO HDN and G-6-PD deficiency.