0060
GONG CHX, YAN CH, ZHU CH BEIJING
CHILDREN’S HOSPITAL, BEIJING, CHINA Objective: To learn
relations between cytokines and the course of diabetes. Method: We determined the levels
of six cytokines in sera of all subjects and calculated 2 ratios of
cytokines from T help cell 1 (TH1) and T help cell 2 (TH2). Group 1, normal
control 30 cases; group 2, newly-diagnosed diabetes mellitus (DM) 26 cases;
group 3, long standing DM 20 cases; group 4, newly-diagnosed GD 9 cases. Results: IL-1b elevated in group 2
patients and decreased in group 3 and 4 patients. IL-2 decreased in group 2
patients, but elevated in group 3 and 4 patients. The level of IL-4 was
decreased in group 2 and 3 patients. The ratios of IL-12 / IL-4 and IFN-g /IL-4 were elevated in
group 2 and 3 patients. Conclusion: The level of IL-1b decreased with the
course going on showed its decreasing followed the finishing of the death
of the b cells in islet. The
decreasing of IL-2 was only in early stage. IFN-g/IL-4 and IL-12/IL-4
were not recovery with course going on, it means the immune system of DM
patients decline to a TH1 bias, Maybe, this bias causes the onset of
diabetes. There were high levels in most kinds of cytokines we determined
on GD. The ratios of IFN-g / IL-4 and IL-12 / IL-4
were not significant in GD when compared with group 1. Our research on
cytokines didn’t show the TH2 bias in GD.
THE CHANGES OF
CYTOKINES ON TYPE 1 DIABETES MELLITUS AT DIFFERENT STAGES