0061
THE ANTIBIOTIC SUSCEPTIBILITY OF S. PNEUMONIAE AND
H. INFLUENZAE AS ETIOLOGIC AGENTS OF THE COMMUNITARY PNEUMONIA, SINUSITIS
AND OTITIS MEDIA M.
Neamtu1, D. Orasanu2,
I. Morari1, L. Dobrota1, C. Cazan1, D.
Bacila1 1Children`s Hospital Sibiu, Pediatric Clinic Sibiu, Romania 2
Central Children’s Hospital “Gr. Alexandrescu”, Bucharest, Romania The objectives of this study were:
establishing of the antibiotic susceptibility for these micro-organisms,
underlying the place of these bacteria in the etiology of airway infections
and infectious ORL pathology, monitoring of antibiotic susceptibility of
these germs obtaining useful information for the antibacterial therapy. The method. The
antibiotic susceptibility was performed by common diffusion method and the
determination of MIC. Up to this moment we have prelevated 646 samples
consisting of sputum, low pharynx aspirate and sinusal and otic pus. We
have obtained 47 H. Influenzae (H.I.) strains and 40 S. Pneumoniae (S.P.)
strains. Results
and conclusions. The performed testing
for antibiotic susceptibility showed up the following: - in
the case of S.P.: negligible/minimal resistance (0 – 24 % of strains) for
Cefaclor, Cefuroxime, Amoxicillin + Clavulanic acid, Ampicillin,
Amoxicillin, Chloramphenicol, Ciprofloxacin, Ofloxacin, Ceftriaxone and
significant/major resistance (> 24 % of strains) for Cefaclor,
Tetracycline, Cotrimoxazol, Erytromycin, Claritromicine, Penicillin; - in the case of H.I.: negligible/minimal resistance (0 – 12,9 %
of strains) for Ciprofloxacin, Ofloxacin, Ampicillin, Amoxicillin,
Amoxicillin + Clavulanic acid, Ceftriaxone, Claritromicine, Tetracycline,
Cefaclor and major resistance (>13 % of strains) for Erytromycin, Cotrimoxazol,
Penicillin, Oxacillin; - the two germs have an important place in the etiology of
communitary pneumonia (10 – 14 % for S.P. and 15 % for H.I.), middle otitis
and sinusitis.
A
Study Sponsored by SmithKline Beecham Foundation Romania