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GONADAL HORMONES PROFILE IN TYPE I DIABETIC FEMALES

Gamal Samy¹, Khaled Taman¹, Mohsen El-Alfy², Nadia Abdel-Satar³ and Mohammed Ehab Embaby¹

¹Medical Department-Institute postgraduate of childhood, ²Pediatric Department, ³Clinical Pathology Department, Ain Shams University- Cairo- Egypt

Objective:-This study aimed to evaluate the gonadotropin hormones leutinizing hormone (LH), follicle-stimulating hormone (FSH) and estrogen in adolescent diabetic girls. Also, leutenizing hormone releasing hormone (LHRH) agonist test was done to determine the site of defect in the hypothalamic- pituitary axis.

Methods:-This longitudinal study was conducted on sixty diabetic girls and

had disturbed mensturuation. They were attending regularly the Diabetic Clinic Children’s Hospital, Ain Shams University. Forty apparently healthy were serving as a control group. Assessment of Serum FSH and LH assay using monoclonal antibodies-based enzyme immunoassay supplied by Eurogenetics and Serum estrogen hormone by using Fertigenix Ez-EASIA immunoassay were done.

Results:-The results of this study showed a highly significant decrease of FSH, LH and E2 in diabetic girls compared to control. There is highly significant increase of gonadotropin and estradiol hormones in good controlled diabetic girls compared to poorly controlled. There is negative correlation between gonadotropin and estradiol hormones, mean blood glucose level, HbA1c% and duration of diabetes. LHRH agonist test showed a highly significant increase of hormonal profile (FSH, LH and E2) in diabetic girls with decrease hormones.

Conclusion:- diabetic girls had low serum level of gonadotrophins and estradiol and reciprocally correlated with the state of glycemic control and duration of diabetes. They respond well to exogenous GnRH suggesting that it is hypothalamic responsibility rather than pituitary defect.