0076

VARIATION OF SERUM CYTOKINES AND ITS CLINICAL SIGNIFICANCE IN CHILDREN WITH FEBRILE CONVULSION

Dong Z Q, Yu C T, Liu Z S, Xiao S B.

Wuhan Children’s Hospital, Wuhan, Hubei, China

Objective: The purpose of the study was to investigate the variation of serum interferon –a (IFN-a), interleukin –8 (IL-8) and tumor necrosis factor-a (TNF-a) in children aged from 6 month to 2 years with simple or complex fibrile convulsion.

Methods: The serum IFN-a IL-8 and TNF-a levels in sixty- Four children with simple febrile convulsion and 52 children cases of complicated febrile convulsion were detected by ELISA and the relationship between serum and TNF-a Levels was studied.

Results: In the group of simple febrile convulsion, the levels of serumIFN-a.IL-8 -a IL-8 and TNF-a were 467.68 + 112.46ng/L, 48.74 + 16.56ng/L and 578.24 + 168.46ng/L, respectively, which were obviously higher than those In the control group (p<0.01).The levels of serum IFN-a, IL-8 and TNF-a In the group of complicated febrile convulsion were 584.56 + 124ng/L, 74.38 + 18.74ng/L and 812.36 + 232.38ng/L, respectively, which were significantly higher than those in control group (p<0.01) and simple febrile convulsion group 9 (p<0.01).There was a positive correlation between serum IL-8 and TNF-a in simple or complicated febrile convulsion (r1=0.565, r2=0.64, p<0.01).

Conclusion 1)In cases of simple or complicated febrile convulsion, serum IFN-a, IL-8 and TNF-a levels increased obviously. It can enhance body’s Immunity to infection, on the other hand, it may irritate immunological Inflammatory reaction, thus causing tissue and cell damage. 2) IL-8 and TNF-a may cooperate in febrile convulsion and involved in the whole pathological process.