0090

FOLLOW-UP OF HELICOBACTOR PYLORI ERADICATION IN CHILDREN

Xiang L, Wen F-Q, Tang Y, Zuo W-H, Li Y-H, Wu B-Q, Li G-F

Dept. of Pediatrics, Second Hospital, Medical College, Ji Nan University, Shenzhen, China

Objective: To explore the short and long-term efficiency of losec, clarithramycin, aomxillin eradicating Helicobactor pylori (H.pylori) infection in children.

Methods: Children with recurrent abdominal pain who were identified with H.pylori infection by both 13C-UBT and Hp-IgG were divided into two groups, therapy group and placebo group. Therapy group was given losec 0.8mg/kg/d, once daily, clarithramycin 15mg/kg/d, twice daily, amoxillin 30mg/kg/d, three times daily. Total therapy course was 1 week. They were followed-up 1,3,6,12 month after stopping therapy.

Results: 1. The effective rate of abdominal pain relief was 96.7% and 34.6% respectively in therapy group and placebo group. The H.pylori eradication rate was 90% and 14.3% respectively. 2. The H.pylori re-infection rate was respectively 1.85%, 1.85%, 3.57% in 3,6,12 after treatment.

Conclusions: 1. The losec triple- therapy is efficient clinically and has a high H. pylori eradication rate. The re-infection rate in 1 year is very low. 2. C-UBT diagnosing H.pylori infection and monitoring its eradication is very simple, safe and accurate.