THE EFFECT OF
NITRIC OXIDE ON ARTERIAL BLOOD FLOW IN NEONATES OF PRE-ECLAMPTIC MOTHERS
Korraa A. Afaf1, Mohamed A. Salah2,
Hassaballah H. Magda1
1 AL-Zahraa
University Hospital, Cairo, Egypt
2 EL-Hussein University
Hospital, Cairo, Egypt
Our aim
is to assess endogenous nitric oxide concentration and to evaluate the
relation between it's level and arterial blood flow velocities in neonates
of pre-eclamptic mothers
Our study was conducted on neonates, classified
into two groups:neonates of pre-eclamptic mothers (included 33 neonates),
and neonates of normotensive mothers (included 12 neonates). All neonates
were subjected to full history taking, through clinical and neurological
investigations, and Doppler ultrasound on head and abdomen to evaluate cerebral.
Mesenteric and renal arteries blood flow velocities.
In the present work, we found that serum levels
of nitric oxide were significantly lower in neonates of pre-eclmptic
mothers incomparison to neonates of normotensive mothers. No difference was
found in NO serum levels between IUGR and normal weight newborn between, or
acidotic and non-acidotic patients. Doppler study reveals a highly
significant increase in cerebral blood flow, mesenteric and renal blood
flow velocities in neonates of pre-eclamptic mothers than neonates of
normotensive mothers. No correlation revealed between NO serum levels and
mesenteric or renal blood flow velocities.
Conclusion: there is a defect in serum NO levels
in infants of pre-eclamptic mothers, our study favor mediators other than
NO, possibly (prostacyclin, acetylcholine) which may be responsible for the
increment of arterialblood flow.