0119

EVIDENCE FOR HUMAN LEUKOCYTE ANTIGEN RELATED SUSCEPTIBILITY FOR IDIOPATHIC -CHILDHOOD ISCHEMIC STROKE

Li-Ping Zou; Yu-Hong Guo; Fang Fang; Hu-Sheng Wu; Eilhard Mix

Division of Neurology, Department of Internal Medicine, Beijing Children’s Hospital, Capital University of Medical Sciences, Beijing, China

Objective: To study the relationship between clinical and immunogenetic features in idiopathic childhood ischemic stroke.

Methods: The data identified 43 patients with ischemic stroke from North China. Diagnosis was established by CT-scan, magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) as well as manifestation. Human leukocyte antigen (HLA) type was performed by a standard microlymphocytotoxicity assay for HLA-A, B, and PCR/SSO typed for HLA-DRB1, DQA1, and DQB1 alleles.

Results: The gene frequencies and relative risk (RR) of HLA-A^-（RR=8.126, X²=19.28） and HLA-B51(RR=6.342，X²=18.94) were markedly increased in the patients, compared with control group p < 0.01. HLA-B17 was markedly decreased in the patients, compared with control group p< 0.01. HLA-DRB1*0802, DRA1*0401 and DQB1*0402（RR=11.78，X²=13.50）were also increased, p< 0.01. There were in one haplotype of DRB1*0802、DRA1*0401 and DQB1*0402. 6/14 patients in HLA-A^- group and 13/17 patients in B51group associated with preceding respiratory infections.

Conclusion: There was a genetic predisposition and susceptibility to idiopathic childhood ischemic stroke that was triggered by transient viral or bacterial precipitants, they contributed causally to vasculitis and vascular occlusion in brain.