0130
SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 IN SERA OF
CHILDREN WITH BRONCHIAL ASTHMA Zheng RX, Chu GL, Zhao H, Kan X Pediatric Department, General
Hospital of Tianjin Medical University, Tianjin, China Objective: To determine whether
bronchial asthma attacks in children is associated with increased levels of
serum soluble intercellular adhesion molecule-1(sICAM-1). Methods: 20 healthy control
children and 20 asthmatic children aged 2 to 8 years old were included in
the study. The concentrations of sICAM-1 were measured in sera of the
controls, and the patients during attack and non-attack of asthma using an
radioimmunoassy. Result: In children with
asthma, The mean (+/- SD) level of serum sICAM-1 in the active phase of
asthma (443.2+/-108.3 ng/ml) was higher than that in the stable phase of
the disease (363.3+/-33.9 ng/ml; p <0.05). Compared to the healthy
controls (183.2+/-22.8 ng/ml), the levels of ICAM-1 in the children with
asthma were significantly increased either in the active or stable phase(p<0.01,
p<0.05, respectively). Conclusion:
ICAM-1
plays a prominent role in the pathogenesis of asthma. It is a promising
serological marker of asthma which would not only indicate inflammation but
also allow the monitoring of therapy and intervention.