0149

LATE VITAMIN K DEFICIENCY BLEEDING IN CHINA

Zhang HF1, Li GS1, Tian XQ1, Shearer MJ2

1 Department of Pediatrics, Second Hospital, Hebei Medical University, Shijiazhuang, China

2 The Vitamin K Units, St Thomas’ Hospital, UK

 

Objective: To expatiate in the feature of late vitamin K deficiency bleeding (VKDB) in infants of China.

Methods: Form 1982 to 1998, the amount of documents of late VKDB aired by Chinese medical journals. We collected 3970 cases of late VKDB. Most infants were previously healthy and had no hepatic or other underlying disease. All infants hadn’t receiving vitamin k prophylaxis.

Results: A total of 3970 cases of late VKDB were analyzed (see Table). The male was 2874 cases while the female was 1079 cases and the male: female was 2.62:1. In the total cases, exclusive breast-fed infants were 3555(89%); predominant breast- fed infants were 300(8%), and the formula-fed were115 (3%) The peak age was 4 –8 weeks (3148, 79%), 316(8%) cases were inferior to 4 weeks and 506 (13%) cases went beyond 8 weeks. The majority (92%), 3674 out of 3970 cases, occurred to intracranial haemorrhage. The numbers of death were 891(22%).

Conclusion:  As there is not conventional vitamin k prophylaxis, VKDB is still a problem. The figures support even more previous impression that the incidence of late in Asia is higher than in Europe. China has a higher incidence.