0157

THE OBSERVATION OF LOVASTATIN TREATMENT HYPERLIPIDEMIA ON NEPHROYIC SYNDROME

Han ZM, Chen XD, Yang DS, Zhang H

First Affiliated Hospital, Xinxiang Medical College, Henan, China

Objective: To investigate the effects of lovastatin treatment hyperlipidemia on nephrotic syndrome with children.

Methods: 43 cases nephrotic syndrome were randomly divided into treatment group and control group. There were 21 cases in treatment group and 22 cases in control group. All of the cases were application prednisone again and the cases of treatment group were application lovastatin. Before treatment and after treatment one month, liver function and serum lipide were measured.

Results: Compared before treatment with after treatment in each group, the level of serum apoprotein B (ApoB), total cholesterol (TC), trigtycerides (TG), low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lpa] were obviously decrease (P<0.01). The concentration of serum ApoB, TC, TG, and LDL-C in treatment group were much lower than that in control group (P<0.01) and Lpa was no obvious difference in treatment one month.

Conclusion: Lovastatin can obviously decrease the level of serum lipide in nephrotic syndrome with children.