0163
Wang Bin, Zhang Mengmeng, Zhu Lijuan, Liu Shuqin Hospital of First Automobile
Work, Changchun, China Objective: To
evaluate the normal levels of serum Osteocalcin or Bone-γ-carboxylutamic acid,
(BGP) and growing state of bone in normal children by the measurement of
serum BGP in normal children of different ages and to offer the theoretical
basis in the diagnosis and treatment of metabolic bone diseases. Methods: The serum
BGP was measured in 1000 healthy children by Radioimmunoassay(RIA),
including 500 boys and 500 girls ,ranging in age from one to fourteen years
old. Results: Quantity of
BGP was between 10.600 - 24.866ng/ml in healthy children from one to
fourteen years old. The older the ages, the higher the BGP levels. The
levels of BGP in girls from one to three years old and from seven to twelve
years old were significantly higher than those in the boys (P<0.01) in
the same age group. But the levels of BGP in boys from 12 to 14 were
significantly higher than these in the girls in the same age groups
(P<0.05). The levels of BGP rapidly rose after 8 years old in the girls
and after 12 years old in boys. Conclusion: The levels of serum BGP in normal
children was associated with the age growing, and body height, and they
were associated with sex at different growing stage. The levels of BGP
indicated that they had important significance at clinic in evaluation of
bone growing of normal children and in diagnosis and treatment of metabolic
bone diseases.
ANALYSIS AND MEASUREMENT Of SERUM BGP QUANTITY IN 1000
NORMAL CHILDREN