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SIGNIFICANCE DETECTING SERUM INTERLEUKIN-6,
INTERLEUKIN-8 AND INTERLEUKIN-10 IN ASTHMATIC CHILDREN
Liu CS, Han Z, Wang Z.
Second Hospital, Tianjin Medical
University, Tianjin, China
Objective: To understand significance of
interleukin-6 (IL-6), IL-8 and IL-10 in asthma attack and relief.
Methods: 30 cases in asthma attack, 8.16±4.17 years of age. 30 cases in
asthma relief, 7.86±3.21 years
of age. 20 cases in control
group, 8.10±3.15 years
of age. IL-6, IL-8 and IL-10 were detected with ELISA technique in three
groups.
Results: The level of serum IL-6 and IL-8 in asthma attack
was significantly higher than that in asthma relief (P<0.05) and control group (P<0.01), but the level of serum IL-10 was significantly
lower than that in asthma relief (P
<0.05) and control group (P<0.01).
The level of serum IL-6 and IL-8 in asthma relief was significantly
higher than that in control group (P<0.05),
but the level of serum IL-10 was significantly lower than that in control
group (P<0.05).
Conclusion: The study confirmed that airway
inflammation of asthma was related to up-regulation of IL-6. And IL-8 and
down-regulation of IL-10 and severe degree of asthma was showed in
different aspect by level of serum IL-6, IL-8 and IL-10 .To different
characteristics of IL-6, IL-8 and IL-10 in asthmatic airway inflammation,
it’s important to take corresponding treatment.
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