0187

STUDY ON CEREBRAL OXYGEN METABOLISM AND CEREBRAL BLOOD FLOW IN HYPOXIC ISCHEMIC ENCEPHALOPATHY MONITORED BY NIRS

Chen S-Y1, Sakatani K1, Zhao S-M2, Pang-N1, et al.

1 Sino-Japan Friendship Hospital, Beijing, China

2 Peking Union Hospital, Peking Union Medical University, Chinese

Academy of Medical Sciences, Beijing, China

 

Objective: We investigated cerebral oxidative metabolism and changes of cerebral blood flow in hypoxic ischemic encephalopathy (HIE), and cerebral function of perinatal brain injury was evaluated by the monitoring of near infrared spectrophotometry (NIRS).

Methods: NIRS could monitored the changes in oxyhemoglobin (HbO2), deoxyhemoglobin(Hb) and total hemoglobin (tHb= HbO2+Hb) before  and after music stimulation (MS) on the frontal surface of brain in newborns in 24 cases of HIE, comparising with 30 cases of normal group.

Results: HbO2, Hb, tHb is remarkably increased after MS in normal group. HIE groups: HbO2,tHb have not differences(p>0.05 ) and Hb were elevated significantly (p<0.05 ) in mild HIE patients, HbO2, tHb were reduced  and Hb were elevated significantly (p0.05 in moderate HIE patients. HbO2, Hb and tHb were reduced significantly in severe HIE patients (p<0.05). There was a significant negative correlation between the severity of HIE and reducing amplitude of tHb (CBF) (r=0.64, p<0.001).

Conclusions: NIRS could detect Brain function of HIE. newborns early, and also could evaluate severe extent of HIE.