0187
STUDY ON CEREBRAL
OXYGEN METABOLISM AND CEREBRAL BLOOD FLOW IN HYPOXIC ISCHEMIC
ENCEPHALOPATHY MONITORED BY NIRS Chen S-Y1,
Sakatani K1, Zhao S-M2, Pang-N1, et al. 1 Sino-Japan
Friendship Hospital, Beijing, China 2 Peking Union
Hospital, Peking Union Medical University, Chinese Academy of Medical Sciences,
Beijing, China Objective: We investigated cerebral oxidative metabolism and
changes of cerebral blood flow in hypoxic ischemic encephalopathy (HIE),
and cerebral function of perinatal brain injury was evaluated by the
monitoring of near infrared spectrophotometry (NIRS). Methods: NIRS could monitored the changes in oxyhemoglobin (HbO2),
deoxyhemoglobin(Hb) and total hemoglobin (tHb= HbO2+Hb)
before and after music stimulation
(MS) on the frontal surface of brain in newborns in 24 cases of HIE,
comparising with 30 cases of normal group. Results: HbO2, Hb, tHb is remarkably increased after
MS in normal group. HIE groups: HbO2,tHb have not differences(p>0.05
) and Hb were elevated significantly (p<0.05 ) in mild HIE patients, HbO2,
tHb were reduced and Hb were
elevated significantly (p<0.05
= in moderate HIE
patients. HbO2, Hb and tHb were reduced significantly in severe
HIE patients (p<0.05). There was a significant negative correlation
between the severity of HIE and reducing amplitude of tHb (CBF) (r=0.64, p<0.001). Conclusions: NIRS could detect Brain function of HIE. newborns
early, and also could evaluate severe extent of HIE.