0205
LEVELS OF BETA-ENDORPHINE IN SERUM AND CEREBROSPINAL FLUID AND
CHANGES IN ERYTHROCYTE IMMUNOLOGICAL FUNCTION IN CHILDREN WITH NERVOUS
SYSTEM INFECTIOUS DISEASES CHEN Yu, SUN Baoli Department of Pediatrics, First Affiliated Hospital of Jiamusi University, Jiamusi,
China Objective: To study the levels of beta-endorphine (β-EP) in serum and
cerebrospinal fluid and the changes in erythrocyte immunological function
in children with nervous system infectious diseases. Methods: Fifty-six children with nervous system infectious
diseases (Observation group) and forty-four aged-matched children with no
nervous diseases (Control group) were selected. The levels of
beta-endorphine in serum and cerebrospinal fluid, the quantity of
complement receptor type I expressed on erythrocytes (ECR1) and the rate of
red cells native adhesion to tumor cells (NTRR) were determined. Results: The levels of β-EP
in serum and cerebrospinal fluid in observation group was obviously higher
than that in control group. Compared with control group, the quantity of
ECR1 had no obvious changes and NTRR obviously fell in observation group.
The levels of β-EP
in cerebrospinal fluid in severe symptom group was obviously higher than
that in light symptom group of observation group, and NTRR in severe
symptom group was obviously lower than that in light symptom group . What
is more, the more severe the disease condition was , the higher the levels
of β-EP in serum and
cerebrospinal fluid were, and the lower NTRR was. Conclusion: Beta-endorphine has dual regulation of erythrocyte
immunological function, and both of them relate to the disease condition.