THE
TREATMENT OF INFECTIOUS BRAIN EDEMA IN CHILDREN BY CHINESE HERBAL MEDICINE （EXPERIMENTAL STUDY）
Yu
PL, Zhang BL, Yue SJ
Department of
Pediatrics, Xiang Ya Hospital, Center Southern University, Changsha, China
Objective: This paper
includes 8 subgroup studies to evaluate the effect and mechanism of several
Chinese herbal medicines for the treatment of infectious brain edema.
Methods:
All subgroups were randomly divided into experimental and control
groups. Name of drugs ① Injection of Ligusticum wallichi Franch and carthamus
tinctorius, ② Tetramethylpyrazine, ③ Anisodamine
Hydrochloride, ④ Baicalin, ⑤ Qingkailing, were
injected for the treatment of infectious brain edema models. Three kind of infectious
brain edema animal
models were used.
Model I was induced by pertussis bacilli, model II was induced by E.Coli,
and model III was induced by glutamic acid.
Results: In model I:
Drug ① reduced the injury of blood brain barrier and
its permeability. Drug ② and ④ reduced the content of brain water, sodium
and Evan’s blue, reduced the intracranial pressure (ICP) and improved the
pathological changes of brain tissue. Drug ② and ④ facilitated
the production of HSP70. In compared with mannitol, the reduction of ICP of
② and ④ were slower
but persisted for a longer duration. The pathological changes of brain
tissue were significantly improved of ② and ④ in compared
with the control and mannitol groups. Drug ③ reduced the water as
well as the glutamate content of the brain. In model II: drug ② reduced the
content of endotoxin, TNFα, TXB2 of CSF, reduced the water
content of brain and improved the pathological change of brain tissuce. Drug
③ reduced both
the water and glutamate content of the brain and reduced the endotoxin,
lactic acid and MDA in CSF. In model III: Drug ⑤ reduced the
brain edema and the Ca2+ content of the synapse of brain, the number of
NMDA of cell membrane of brain were reduced too.
Conclusion: The above
studies showed that all the above 5 drugs were effective for the treatment
of brain edema in the experimental animal models. These results might
induce a kind of new treatment for clinical infectious brain edema.