THE LOWER LEVEL
OF SERUM IgG SUBCLASSES IN INFANTS WITH FIRST TIME LOWER RESPIRATORY TRACT
INFECTION
Dai J-H
Children’s Hospital, Chongqing University of Medical
Science, Chongqing, China
Objective: To
study the level of serum IgG subclasses in the infants with first time
lower respiratory tract infection.
Methods: For
185 infants with the first time lower respiratory tract infection, the
levels of serum IgG,IgA,IgM and IgG subclasses were detected by ELISA. The
results were compared with the reference values from the local healthy
infants. The values that were below the lower limits of the reference
values were regarded as the lower level of Ig or IgG subclasses, while the
values that were beyond the higher limits of the reference values were
regarded as the higher level of Ig or IgG subclasses.
Results:
Among the 185 patients with first time respiratory tract infection, 43 of
them whose IgG were at lower levels had the lower levels of IgG subclasses.
And 120 patients had the lower levels of IgG subclasses in 142 left with
the normal IgG levels. The ratio of the patients with the lower levels of
IgG subclasses was 84.51%. Among the 34 patients from birth to three months
old, 29 of them had the lower levels of three or four kinds of IgG
subclasses. The ratio of these patients with the lower levels of IgG
subclasses was 85.29%, which was the highest in all ages.
Conclusions:
Both lower levels of serum IgG and IgG subclasses were found in the infants
with first time lower respiratory tract infection. The younger, the more
likely to have the lower levels of IgG subclasses.