0254

A study on relationship between GSTμgene deletion and SLE susceptibility

JIANG H, Wang SL, Luo G

Department of Pediatrics, First Clinical College, China Medical University, Shenyang, China

Objective: Glutathione s-transferaseμ(GSTμ) gene deletion produces deficiency of anti-oxydation funciton.Free radicals and their reaction products damage DNA and induce to formation of auto-antibody and circulating immunocomplex. These constitute pathogenic basis of systemic lupus erythematosus(SLE). The study aim to evaluate the relationship between GSTμ gene deletion and SLE susceptibility.

Method: Polymerase chain reaction (PCR) method was used to investigate the rates of GSTμgene deletion in 22 children, 23 healthy children, 113 adults with SLE and 237 healthy adults.

Results: The rate of GSTμ gene deletion in children with SLE was 90.91%, which was significantly higher than that of the healthy children, 56.52% (x²=6.80, P<0.01, OR=7.69, 95%CI=1.82-32.52).And the rate of GSTμgene deletion in adults with SLE was 61.95%,which was higher than that of the healthy adults, 50.63% (x²=3.95, P<0.05, OR=1.59, 95%CI = 1.01-2.51).The rate in children with SLE was significantly higher than that of adults with SLE (x²=6.95,P<0.01, OR=6.14, 95%CI=1.60-23.52).

Conclusion: GSTμgene deletion may play an important role in etiopathology of SLE, the smaller in age, the more evident in susceptibility.