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Change of serum nitric oxide and lipid peroxide levels in children with lupus nephritis

Luo G, Jiang H, Wang SL

Pediatrics, First Clinical College, China Medical University, Shenyang, China

 

Objective: To determine the levels of serum nitric oxide (NO) and lipid peroxide (LPO) of patients with lupus nephritis (LN), and analyse the relationship between them and effects on LN.

Methods: The serum levels of No and LPO of LN patients (18 active LN patients and 16 stable LN patients) and 23 healthy subjects were determined by chemical analysis methods.

Results: The levels of serum NO (79.16±18.03) umol/L LPO (9.87±1.72) umol/L of active LN group were higher than those of healthy subjects group NO (51.06±7.99) umol/L LPO (5.87±1.40) umol/L.The levels of serum NO(59.41±15.27) umol/L LPO (6.40±1.58) umol/L of stable LN group were lower than those of active LN.And there were significantly no difference between stable LN group and healthy subjects group. The obvious positive correlations were observed between NO and LPO, anti-ds-DNA, gamma-globulines. The obvious negative correlation was observed between NO and C3. The obvious positive correlations were observed between LPO and anti-ds-DNA, gamma-globulines, the obvious negative correlation was observed between LPO and C3.

Conclusion: There is oxidative injury in active LN patients. The relationship between oxidative injury and NO is sure. The level of serum NO, LPO can be considered the important standards of LN activity. The application of anti-oxidation therapy in LN is rendered.