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Change of serum nitric oxide and lipid peroxide levels
in children with lupus nephritis Luo G, Jiang H, Wang SL Pediatrics,
First Clinical College, China Medical University, Shenyang, China Objective: To determine the levels of serum nitric
oxide (NO) and lipid peroxide (LPO) of patients with lupus nephritis (LN), and
analyse the relationship between them and effects on LN. Methods: The serum levels of No
and LPO of LN patients (18 active LN patients and 16 stable LN patients)
and 23 healthy subjects were determined by chemical analysis methods. Results: The levels of serum NO (79.16±18.03) umol/L LPO (9.87±1.72) umol/L of active
LN group were higher than those of healthy subjects group NO (51.06±7.99) umol/L LPO (5.87±1.40) umol/L.The levels
of serum NO(59.41±15.27) umol/L LPO (6.40±1.58) umol/L of stable
LN group were lower than those of active LN.And there were significantly no
difference between stable LN group and healthy subjects group. The obvious
positive correlations were observed between NO and LPO, anti-ds-DNA, gamma-globulines.
The obvious negative correlation was observed between NO and C3.
The obvious positive correlations were observed between LPO and
anti-ds-DNA, gamma-globulines, the obvious negative correlation was
observed between LPO and C3. Conclusion: There is oxidative
injury in active LN patients. The relationship between oxidative injury and
NO is sure. The level of serum NO, LPO can be considered the important
standards of LN activity. The application of anti-oxidation therapy in LN
is rendered.