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CLINICAL STUDY ON PREVENTING AND CURING CORONARY ARTERY LESIONS BY INTRAVENOUS g-GLOBULIN TREATMENT IN KAWASAKI DISEASE

Teng YE, Yao F

Department of Pediatrics, The 1^st Clinical College, China Medical University, Shenyang, China

Objective: In order to find more effective method to prevent and treat coronary artery lesions in Kawasaki disease, we evaluated the efficacy of intravenous g-globulin (IVGG) administration on children with Kawasaki disease.

Methods: 39 patients with Kawasaki disease were divided into two groups occasionally, whose history was all in 7 days. IVGG was used in one group, which included 18 patients. The other was control group, including 21 patients. The progression of coronary artery lesions was monitored by serial echocardiography before, two weeks and six months after the treatment.

Results: The symptoms (such as fever, lymphitis et al.) disappeared more quickly in IVGG group. Most of all, of 18 patients (IVGG group), no one had coronary artery lesions, but in the control group, 6 of 21 (28.57%) had coronary artery lesions. The difference was obvious (P<0.05).

Conclusion: IVGG therapy can prevent and reduce the onset of coronary artery lesions in Kawasaki disease. It is more effective method on treating Kawasaki disease.