Text Box: ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEREDITARY HAEMOLYTIC ANEMIA Fang J-P, Huang S-L, Chen C, Zhou D-H, Wu Y-F, Bao, R Hematopoietic Stem Cell Transplantation Center, Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, China Objective: To examine the feasibility of allogeneic peripheral blood stem cell transplantation (allo-PBSCT) for the heredity haemolytic anemia (HHA). Methods: Allo-PBSCTs were performed on 3 patients with β-thalassemia major and 1 patient with congenital idiopathic anemia by HLA-identical siblings’donors or 1 loci-mismatch parent. The harvested stem cell contained nucleated cells 4.7-14.4×108/kg recipient weight, CD34+CD38－cells 4.8-32.9 × 106/kg and colony-forming-unit-granulocyte- macrophages (CFU-GM)3.22-9×105/kg. The Conditi-oning regimen was consisted of busulfan, cyclophosphamide, melphalan, thoitepa, fludarabine and antithymocyte globulin (ATG). Results: All patients were engrafted and accomplished with the acute-versus-host disease (GVHD). A patient had the controlled chronic GVHD. 3 patients are survival with ex-anemia. Their Hb have been maintaining at normality without transfusion. One died of the hepatic veno-occlusive disease. Conclusion: Allo-PBSCT is an effective method to treat the diseases, suggesting a new way to the β- thalassemia major and congenital idiopathic anemia.

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