EFFECTS OF RETINOIDS ON THE PRODUCTION OF CYTOKINES OF THE CHILDREN WITH RECURRENT RESPIRATORY INFECTION

Zhang JH1, Qian YQ2, Zheng DY2

1 Air Force General Hospital, Beijing, China

2 The Second Affiliated Hospital, West China University of Medical

 Sciences, Chengdu, China

 

Objective: To study the effects of retinoids(retinol、retinoic acid、retinyl acetate) in vitro on the production of interleukin 1(IL-1)、interleukin 2(IL-2) of peripheral blood mononuclear cells(PBMC) from the children with recurrent respiratory infection(RRI).

Methods: The activities of IL-1、IL-2 of the PBMC from RRI children and the changes of IL-1、IL-2 activities after PBMC cultured with 10-9 mol/L retinoids were measured.

Results: The activities of IL-1、IL-2 of PBMC from RRI children were 0.46±0.06μg/L、12.7±1.5IU/L respectively ,lower than normal control and could be restored to normal levels  after cul-

tured with retinoids.The effect of retinoic acid is most strong ,the next is retinyl acetate,retinol is most weak..

Conclusions: The production of IL-1、IL-2 of  PBMC from RRI children can be enhanced by retinoids and restored to normal.

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