THE LOWER LEVEL
OF SERUM IgG SUBCLASSES
IN INFANTS WITH
FIRST TIME LOWER RESPIRATORY TRACT INFECTION
Dai J-H
Children’s
Hospital, Chongqing University of Medical Science, Chongqing, China
Objective: To study the level of serum IgG
subclasses in the infants with first time lower respiratory tract
infection.
Methods: For 185 infants with the first time lower
respiratory tract infection, the levels of serum IgG, IgA, IgM and IgG
subclasses were detected by ELISA. The results were compared with the reference
values from the local healthy infants. The values that were below the lower
limits of the reference values were regarded as the lower level of Ig or
IgG subclasses, while the values that were beyond the higher limits of the
reference values were regarded as the higher level of Ig or IgG subclasses.
Results: Among the 185 patients with first time
respiratory tract infection, 43 of them whose IgG were at lower levels had
the lower levels of IgG subclasses. And 120 patients had the lower levels
of IgG subclasses in 142 left with the normal IgG levels. The ratio of the
patients with the lower levels of IgG subclasses was 84.51%. Among the 34
patients from birth to three month old, 29 of them had the lower levels of
three or four kinds of IgG subclasses. The ratio of these patients with the
lower levels of IgG subclasses was 85.29%, which was the highest in all
ages.
Conclusions: Both lower levels of serum IgG and IgG
subclasses were found in the infants with first time lower respiratory
tract infection.The younger, the more likely to have the lower levels of
IgG subclasses.