0308

INQUIRE INTO THE CAUSES OF CONGENITAL HEART DISEASE, IMMUNIZATION FUNCTION, TRACE ELEMENTS AND MENTAL DEVELOPMENT

Guo Q.M., Huang H.L.

Quanzhou Children’s Hospital, Fujian ,China

Objective: To probe into the hereditary cause of children’s congenital heart disease (CHD), to appraise immunization function of these patients and to research into the clinical sense by changing the trace elements in these patients who suffer from CHD and the mental devolopment problems as well.

Methods: 48 outpatients with CHD who were subsequently visited in the recent three years. Investigation included the history of family and the history of pregnancy. Checking involved their plain chest X-ray, Electrocardiogram and Echocardiogram, OKT value, immunoglobulin, trace elements and IQ.

Results: 1. Clinical types of children with CHD: 18 cases of ventricular septal defect; 15 cases of atrial septal defect (ASD Ⅱ); 7 cases of patent ductus arteriosus;4 cases of tetralogy of fallot, 2 cases of pulmonary stenosis,1 case coarctation of the aorta (45XO).2 cases of atrial septal defect (ASDⅠ)(Down Syndrome). 2. The value of CD3, CD8 in these patients were significantly higher than those in normal (P<0.01), while CD4, CD4/CD8 were no obviously different (P>0.05). IgA IgM in blood were significantly higher than those in normal (P<0.01). Low blood zinc and high blood copper (P<0.01) and, iron, calcium, magnesium in blood are no obviously different (P>0.05). 3. The value of IQ in most of these patients were reduced to a normal minimum.

Discussion: 1. The main causes in these patients are either heredity or environment. With regard the hereditary factor, prenatal Echocardiogram can be done to pregnant women in danger to make a clear diagnose and prompt treatment afterwards and to achieve the goal of eugenics and birth control. 2. The determination of the immunizatoin function of the children with CHD shows that the cell and body fluid immunity in these patients were in a chaotic state, and easy to cauuse infection. 3. Low blood zinc and high blood copper in these patients needs to make a further study. 4. The value of IQ in most patients remains in normal minimun. This must have something to do with movable ability restricted; over- protection by parents, frequent illness and uneasy feeding in the early stage.