0311

EFFECTS OF NIMODIPIN AND KETAMINE ON CEREBRAL BLOOD FLOW AND METABOLISM IN CEREBRAL

ISCHEMIC RABBITS

Qian S-Y, Fan X-M, He Y-X, Shen H-Q, Yin H-H

Beijing Children’s Hospital, Beijing, China

Objective: To study the effects of nimodipin and ketamine on cerebral blood flow and metabolism in rabbits with global ischemic-reperfusion.

Methods: The model of global cerebral ischemic-reperfusion was produced in rabbits. They were randomly divided into four groups: sham-operated group, ischemic group, nimodipin group, ketamine group.

Results: 1) The mean flow velocity (Vm) of middle cerebral artery (MCA) in ischemic group was significantly reduced during the 24 hours of reperfusion (p<0.001) compared with that of pre-ischemia. 2) Compared with before operating, the plasma lactic acids in all four groups were significantly increased during the 24 hours of ischemic-reperfusion (p<0.05). The plasma lactic acids were higher and arteriovenous oxygen differences (AVDO₂) were wider in both ischemic group and nimodipin group than non- ischemic control group and ketamine group during the 24 hours of reperfusion (p<0.001). 3) Mean blood pressure and heart rate fell after nimodipin was used.

Conclusion: This study suggested that both nimodipin and ketamine could improve intracranial blood flow velocity of rabbits. Ketamine could also decrease plasma lactic acid and AVDO₂. Low-dose Ketamine may have some protective effects on rabbits with ischemica-reperfusion. The cause of nimodipin didn’t improve the metabolism and outcome of this group rabbits may correlated to its effects on restraining the functions of cardiovascular system.