A
CLINICAL STUDY OF INFANT HEPATITIS B VIRUS-ASSOCIATED GLOMERULONEPHRITIS
Xie Y-Z, Zhen W-H.
Department of Pediatrics, Taijiang Hospital,
Fuzhou, Fujian, China
Objective: To understand the
situation of the infant hepatitis B virus-Associated glomerulonephritis
(HBV-GN) in infantile glomerulopathy at home.
Methods: Clinical analysis and
study were made in 27 sick children diagnosed as HBV-GN clinically and
pathologically in the five years from June 1992 to May 1997.
Result: There were 22
males and 5 females. The ratio of male to female was 4.4:1, aged from 1
10/12 to 13 years old. In clinical manifestation, 9 cases had proteinuria
and hematuria, and 8 cases nephrotic syndrome, 6 cases acute nephritic
syndrome, 3 cases asymptomatic proteinuria and 1 case simple hematuria. In
pathologic pattern, 15 cases were MN, 7 cases were MsPGN and 4 cases were
ECPGN, 1 case was MPGN. The proportion of ECPGN (14.8%) is significantly
higher than that reported in literature at home. This may be something to
do with early confirmed diagnosis. All the 27 cases were identical with the
diagnostic criterion of infantile HBV-GN adopted recently at home. The
cases in this group account for 26.7% (27/101 cases) of the total case in
the infantile biopsy in the same period of our department. 13 cases were
treated with subcutaneous injection of heparin (some of whom were treated
with extra prednisone and/or interferon). The effective rate was 85%.
Conclusion: Our country is the area
of highmobidity in HBV-GN which has become a major disease which does harm
to infantile health in our country.
We have emphasized that the sick children clinically diagnosed as
acute glomerulonephritis with serum HBV antigen positive, if serum ASO is
not high, renal biopsy should be conducted to raise the rate of early
diagnosis of HBV-GN. Subcutaneous
injection of heparin is an effective therapy in the treatment of infantile
HBV-GN