A CLINICAL STUDY OF INFANT HEPATITIS B VIRUS-ASSOCIATED GLOMERULONEPHRITIS

Xie Y-Z, Zhen W-H.

Department of Pediatrics, Taijiang Hospital, Fuzhou, Fujian, China

 

Objective: To understand the situation of the infant hepatitis B virus-Associated glomerulonephritis (HBV-GN) in infantile glomerulopathy at home.

Methods: Clinical analysis and study were made in 27 sick children diagnosed as HBV-GN clinically and pathologically in the five years from June 1992 to May 1997.

Result: There were 22 males and 5 females. The ratio of male to female was 4.4:1, aged from 1 10/12 to 13 years old. In clinical manifestation, 9 cases had proteinuria and hematuria, and 8 cases nephrotic syndrome, 6 cases acute nephritic syndrome, 3 cases asymptomatic proteinuria and 1 case simple hematuria. In pathologic pattern, 15 cases were MN, 7 cases were MsPGN and 4 cases were ECPGN, 1 case was MPGN. The proportion of ECPGN (14.8%) is significantly higher than that reported in literature at home. This may be something to do with early confirmed diagnosis. All the 27 cases were identical with the diagnostic criterion of infantile HBV-GN adopted recently at home. The cases in this group account for 26.7% (27/101 cases) of the total case in the infantile biopsy in the same period of our department. 13 cases were treated with subcutaneous injection of heparin (some of whom were treated with extra prednisone and/or interferon). The effective rate was 85%.

Conclusion: Our country is the area of highmobidity in HBV-GN which has become a major disease which does harm to infantile health in our country.  We have emphasized that the sick children clinically diagnosed as acute glomerulonephritis with serum HBV antigen positive, if serum ASO is not high, renal biopsy should be conducted to raise the rate of early diagnosis of HBV-GN.  Subcutaneous injection of heparin is an effective therapy in the treatment of infantile HBV-GN

 

 
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