PRETERM
INFANTS BONE TUREOVER AND EFFECT OF EARLY PARENTERAL CALCIUM IN BONE
TUREOVER
Xu YP, Yu HM
Children Hospital of Medical College of Zhejiang
University, Hangzhou, China
Objective: To
explore change in biochemical markers of bone turnover such as serum
osteocalcin (OC), Carboxyterminal telopeptide type I collangen (ICTP),
Alkaline phosphatase (AKP) in preterm infants, and effect of early
parenteral calcium in them and serum calcium, phosphate and urine calcium,
phosphate.
Methods: 40
preterm infants were divided into parenteral calcium group and control
group. We collected blood and urine samples from them at 24 H and again at
11 day. Serum OC was measured by ELISA, serum ICTP with radioimmunoassay
kid, serum calcium, phosphate, AKP and urine calcium, phosphate, creatine
with entirely automatic biochemical analyzer. The parenteral calcium group
was infused 10% glucosenate calcium 4 ml/kg.d by vein. Moreover, they are
compared with 22 term infants.
Result: At
24 h, serum AKP, ICTP (147.86±44.87 IU, 57.36±6.34 ug/l) in preterm infants were markedly higher than those (147.86±44.87 IU, 57.36±6.34 ug/l) in term infants, and
negatively correlated with gestational age and birth weight (r =-0.528,
p<0.01; -0.614, p<0.01), but serum OC (648.77±238.89 nmmol/l) in preterm infants were lower than those (851.68±238.69 nmmol/l) of term infants, and positively correlated with
gestational age and birth weight (r = 0.359, p<0.05; 0.376, p<0.01).
Again at 11 d, serum OC (947.25±335.47
nmmol/l) in preterm infants were markedly elevated and reached the level of
term infants (941.65±297.28 nmmol/l), but serum ICTP
(65.44±6.24 ug/l) in preterm infants
was elevuately higher than the level of term infants (57.10±3.48 ug/l), serum AKP in parenteral calcium group was higher than
control group, serum OC and ICTP not markedly different. Serum calcium,
urine calcium were elevated in the parenteral calcium group,and serum
phosphate, urine phosphate were reduced.
Conclusion:
There were active bone formation and bone resorption in preterms. Alone
parenteral calcium in birth early cannot increase bone protein formation
and decrease bone collagen degradation, and elevated serum calcium and
urine calcium levels, but didn’t find blood urine and renal
calcification in short duration.