0328
Sun Lingxin, Liu
Xingguo, Xu Sudan, et al. The PLA 210th Hospital, Dalian, China Objective: To evaluate the
therapeutic effects of Levamisole liniment (LMS -L) in children with asthma
and important role of tumor necrosis factor-alpha (TNF-α)and interleukin-2
(IL-2)in the pathogenesis of the diseases. Methods: The 52 patients with
asthma were divided into two groups (LMS-L group had 32 cases and control
group had 20cases) randomly. Every child in both groups was inhaled routine
treatment of ventolin inhaler and Beclomethasone Dipropionate 250 inhaler,
The children of LMS-L group were additionally treat with LMS-L on surface
of the skin, once every 5days for 3 months. TNF-αand IL-2 were examined
in both groups before and after treatment by radioimmunoassay, pulmonary
function were measured 4times before and after treatment. there was another
normal group. Results: During acute phase of
children with asthma, The mean level of TNF-αwas much higher (0.75±0.31ng/ml) in chlidren
with asthma than those in normal children (0.32±0.11ng/ml)(P<0.01),
IL-2 was lower (1.62±0.50ng/ml) compared with those of the
normal children (3.31±0.36ng/ml) (P<0.01). After treatment,
The concentration of TNF-αwas no significant
differences (P>0.05), IL-2 was distinct differences compared with normal
group (P<0.01). Treatment with LMS-L produced significant improvement in
pulmonary function in 3 months. Conclusion: The therapeutic effect
of LMS-L in children with asthma is safe and effecrive.It not only gain
favourable adjust of immune function but also achive therapeutic object.
TNF-αand IL-2 play a
important role in children with asthma and help evaluating its severity and
guiding the effects of treatment. No side-effect of drug was observed. Key Words: Levamisole liniment TNF-α, IL-2, pulmonary
function, asthma
TREATMENT
OF LEVAMISOLE LINIMENT IN CHILDREN WITH ASTHMA