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URINARI TRACT INFECTION (UTI) IN THE NEWBORN CHILDREN Sentsova TB, Akoev YS, Pinaeva AR Research Center for
Children’s Health, Moscow, Russia Immunomicrobiological
peculiarities of bacterial UTI were studied in 102 (premature + mature)
newborns. 75% of urine isolates
E.coli demonstrated P fimbria, in 66,7% of them of pоly type I.
E.coli, isolated from the term babies with UTI was characterized by more
frequent presence of phosphatase, DNA positive germs and more marked
hemolytic activity compared to that from preterm babies. The abstence of the simultaneous isolation
of bacterial P fimbria in urine and P erythrocyte,s antigen spoke in favour
of transient bacteriuria in the newborns. Bacterial UTI in the newborns were
characterized also by the activation of anti lipid A antibodies, elevation of
secretory immunoglobulins in coprofiltrates, complement system disbalance and
decrease of microbicial activity of neutrofiles. Elevated concentrations of
 2-microglobulin in serum (11.48 2.07 mg/ml) in
healthy newborns pointeed on the functional immaturity and insufficiency of
kidney tubular reabsorbtio! n and filtration rate high 
2-microglobulin urine excretion (19.039.22 mg/ml), observed in
the newborn babies with UTI was most
likely connected with the tabular
disfunction. |
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