0336
THE CHANGES OF INSULIN LIKE GROWTH FACTOR-I(IGF-I) AND IGF BINDING PROTEINS
DURING GLUCOCORTICOID TREATMENT IN CHILDREN WITH NEPHROTIC SYNDROME Dong F*, Zhou X*, Pang N*,
Wei M** * China-Japan Friendship
Hospital, Beijing, P. R. China ** Beijing Union Hospital,
Beijing, P. R. China Object: In this study, we tried to find out the changes of serum IGF-I
and Insulin-like growth factor binding proteins (IGFBPs) in nephrotic
syndrome (NS) and the effect of glucocorticoid on serum IGF-I and IGFBPs.
This may be some helpful for finding out the reason and benefit to the
prevention of growth retardation in NS. Method: We measured the serum IGF-I and IGFBPs level of 36 children with
nephrotic syndrome by RIA and IRMA, including: active stage group (ANS, n=12), remission stage group (RE,
n=12), active stage group with glucocorticoid treatment (GNS, n=12) and
normal control group (NC, n=10). Result: 1) Comparing with normal control (NC), serum levels of IGF-I and
IGFBP-3 were decreased(54±9 vs 306±38;1631±286 vs 3854±384,P<0.01) in ANS group; serum levels of IGFBP-1 and IGFBP-2
were increased (231±38 vs 152±16;3299±389 vs 866±90,P<0.01); 2)Serum levels of IGF-I and IGFBP-3 in RE Group were higher than
that in ANS Group (484±107 vs 54±9;4967±532 vs 1631±286, P<0.01) ;IGFBP-1 and IGFBP-2 were lower than that in ANS Group (101±17vs
231±8;671±56 vs
3299±389,P<0.01);3)Comparing with ANS group, serum levels of IGF-I and IGFBP-3 were increased in GNS group
(310±47 vs 54±9 ; 3619±282 vs 1631±286,P<0.01); serum levels of IGFBP-1
and IGFBP-2 were decreased respectively (154 ±20 vs 231±8;1573±197 vs
3299±389,P<0.01);
4)A
correlation was found between serum levels of IGFBP-3 and Albumin in active
stage(r=0.76,
P<0.01) ; and a correlation between serum levels of IGF-I and IGFBP-3
and there was a inverse correlation between serum level of IGF-I and serum
levels of IGFBP-1 and IGFBP-2 in ANS group, Any correlations in other
groups could not be found. Conclusion: 1)The serum
levels of IGF-I and IGFBPs can be changed in active stage of children NS,
but return to normal in remission stage; 2)Glucocorticoid treatment may have a influence on serum IGF-I and
IGFBPs in NS; 3)The changes of
IGF-I and IGFBPs may play a role in the growth retardation of NS children.