To investigate the protective effect of compound protein zinc
(CPZ) in mice cardiac damage induced by CVB3m myocarditis
Wang ZX, Hao FZ, Xu CW, Li JS, Zhang ZH, Qiao YH
Second
Hospital, Shandong University, Jinan China
Objective: To observe the protective
effect and mechanism of compound protein zinc (CPZ) in mice myocarditis
induced by virus.
Methods:
To observe SOD activities and oxygen free radical (OFR) levels of acute
myocarditis mice induced by CVB3m. To observe the cardiac muscle pathologic
damages of mice by light microscope and electric microscope.
Results: Mortalities of CPZ and
CPZ plus VitC and VitC and no-treated groups are 10% and 10% and, 50% and 90%,
respectively; Mortalities of CPZ ,
CPZ plus VitC groups depress significantly than group of no-treated
compared，the mortality of CPZ
group is as well as CPZ plus VitC group depress slightly than group of VitC
group (p>0.05). Necrosis and inflammation of all CPZ groups lower significantly
than no-treated and VitC groups (p<0.001). SOD activities of all CPZ
groups were much higher than no-treated and VitC groups, but lower
significantly than normal group (p<0.001)，the OFR levels were
lower significantly than non-treatment and VitC groups but higher than
normal control group (p<0.001).
Conclusion: OFR played important role
in virus myocarditis. Application of CPZ in the early virus myocarditis
could decrease significantly cardiac muscle damage and mortalities of
infective mice by elevating SOD activities and cleaning out OFR,
accordingly, improve efficiently prognosis, and advantage than VitC，offers possibility for
treating virus myocarditis with CPZ in clinic.