0341

THE PROTECTIVE EFFECT OF (SOD) IN MICE MYCARDITIS INDUCED BY CVB3M

Wang ZX, Hao FZ, Xu CW, Li JS, Zhang ZH, Qiao YH

Second Hospital, Shandong University, Jinan, China

Objective: To investigate the effect and mechanism of superoxide dismutase (SOD) in mice in mice myocarditis induced by CVB3m.

Methods: To observe SOD influences in Mortalities and SOD activities and oxygen free radical (OFR) levels of the acute myocarditis mice. To observe the cardiac pathologic change of mice by light and electric microscope.

Results: Mortality races of small SOD and big SOD doses and small doses SOD plus VitC and VitC and non-treated groups are 20% and 30% and 50% and 50% and 90%, respectively. Mortalities of small and big dose SOD groups lower significantly than group of no-treated compared，the difference among other groups are not significant. Necrosis and inflammation of all SOD groups ware lower than non-treated and VitC group (p<0.001). SOD activities of all SOD treated groups elevated significantly than no-treated, but depress significantly than normal groups (p<0.001). The OFR levels depress significantly than without treatment group but elevated than normal group (p<0.001). SOD activities of SOD small and big dose treated groups elevated significantly than VitC group also, but the OFR levels depress (p<0.001). Differences of small dose SOD plus VitC and VitC groups ware not significant in SOD activities and OFR levels (p>0.05).

Conclusion: OFR play important role in virus myocarditis. Application of SOD in the early virus myocarditis, could decrease significantly cardiac damage and Mortalities of infection mice by elevating SOD activities and cleaning out OFR, accordingly, and advantage than VitC.