0355

CLINICAL ANALYSIS OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS) IN 108 CASES

Guo Y-H, Lin J, Wu J-X, Yang Q-L, Huang Q-Y

Fuzhou Children’s Hospital, Fuzhou, Fujian, China

Objective: To explore the clinical feature and clinical significance of SIRS in infants and children

Methods: The clinical data of 108 cases of SIRS admitted to Fuzhou Children’s Hospital during the years from January 1998 to January 2001 were analyzed. The patients arranged in age from 2 months to 12 years, 67 were males and 41 were females. The ratio between the male and the female was 1.6:1. The course of disease varied from 4 hours to 10 days.

Results: All patients manifested with fever, the temperature varied from 38℃ to 40℃, accompanied by multiple organs involved symptom and sign such as headache, lethargy convulsion, cough, sore throat, diarrhea, abdominal pain, chest pain, palpitation, eruption, diminished heart sound, cold all extremities and so on. White blood cell count in all cases was 12～30Î10⁹/L, band granulocyte is more than 10%. By early use of high dose of antibiotics combined with glucocorticoids, vitamin E, ibuprofen and intravenous immunoglobulins (IVIG), along with the measure to protect the main organs and nutrition supporting, 100 cases (92.59%) were cured, 7 improved (6.49%) and 1 died (0.92%).

Conclusion: It is very valuable and significant that the SIRS is used as diagnosis in clinic. Early diagnosis and prompt treatment could reduce the mortality on patients with SIRS. It is also helpful to improve the prognosis in patients with SIRS and avoid dispute in medical treatment. But diagnosis standard of SIRS is not precise enough, it need to be improved in future.