0357

STAGE III, IV NEUROBLASTOMA AND PREOPERATIVE THERAPY

Cao W-G, Zhang J-Z

Beijing Children's Hospital, Beijing, China

 

Objective: To discuss clinical effect, the indication of preoperative chemotherapy and the optimal time for operation after chemotherapy.

Methods: From Jan. 1991 to Dec. 2000, 96 cases of stage III, IV neuroblastoma were reviewed. Sixty-eight cases underwent tumor resection after chemotherapy, and the other 28 patients received primary surgery without preoperative chemotherapy.

Results: Duration of preoperative chemotherapy was (3.04±1.67) months, and operations were performed after chemotherapy in (2.2±0.5) weeks. Tumor size was generally reduced with (59.5%±28.7%) (P0.01; in preoperative chemotherapy group following chemotherapy with lowering the stage (P0.05. Resectability rate in preoperative chemotherapy group(total ectomy and sub-total ectomy: 89.7%) was significantly higher than that in primary resection group (60.7%) (P0.01).

Conclusion: Preoperative chemotherapy may reduce tumor size and lower the stage, result in higher respectability rate. The operative timing depends on the reduction of the tumor size.