0357
STAGE III,
IV NEUROBLASTOMA AND PREOPERATIVE THERAPY Cao W-G, Zhang J-Z Beijing Children's
Hospital, Beijing, China Objective: To discuss clinical
effect, the indication of preoperative chemotherapy and the optimal time
for operation after chemotherapy. Methods: From Jan. 1991 to Dec.
2000, 96 cases of stage III, IV neuroblastoma were reviewed. Sixty-eight
cases underwent tumor resection after chemotherapy, and the other 28
patients received primary surgery without preoperative chemotherapy. Results: Duration of preoperative
chemotherapy was (3.04±1.67) months, and operations were performed after
chemotherapy in (2.2±0.5) weeks. Tumor size was generally reduced with
(59.5%±28.7%) (P<0.01=; in preoperative
chemotherapy group following chemotherapy with lowering the stage (P<0.05=. Resectability rate in
preoperative chemotherapy group(total ectomy and sub-total ectomy: 89.7%)
was significantly higher than that in primary resection group (60.7%) (P<0.01). Conclusion: Preoperative
chemotherapy may reduce tumor size and lower the stage, result in higher
respectability rate. The operative timing depends on the reduction of the
tumor size.