Text Box:  PRE-NATAL CHLAMYDIAL INFECTION
 Evsiukova I., Koroliova L., Kovalevskaya O., Levshin I.
 Obstetrics and Gynecology Research Institute named Ott, 
 Russian Academy of Medical Science, St.-Petersburg

Objective: Clinical signs of pre-natal chlamydial infection and efficacy of Sumamed and Erythromycin treatment were assessed in 150 newborn children.
Methods: Analyses of urine and scrapes from mucosa of lower eyelid back side of throat and vagina. PCR and isolation of C. trachomatis in cell culture McCoy and L-929, and immunoenzymal determination of specific IgA и IgG antibodies in blood were used.
Results: The newborn children were observed under the following conditions.  Generalized infection and localized forms. There were acute and persisted or latent forms of disease. Severity of clinical symptoms does not depend from presence of IgG antibodies and its level. Incidence of diagnosis of C. trachomatis in urine and scrapes from mucosa of lower eyelid, back side of throat and vagina was 73%, 54%, 12% and 11,5% correspondingly. Treatment of acute form of disease with erythromycin leads to clinical recovery, but persistence of C. trachomatis remains in 47% of children. Treatment with azythromycin (Sumamed) in course dose of 30 mg/kg demonstrated high clinical and microbiology efficacy with no relevance to treatment schedule. 8 children with localized infections were treated with new course dose (3 times with 6-day interval). That dosage regimen is perspective for the second stage of the treatment in patients with latent or persisted infection. 
Conclusion: Treatment of pre-natal chlamydial infection should be performed taking in consideration the clinical course of the disease. Sumamed is the drug of choice that provides clinical recovery and elimination of pathogen.

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