0360
NITROZAMINES IN CHILDREN WITH CHRONIC
GASTRITIS Marian Krawczyński, Iwona Ignyś,
Maciej Borucki Department
of Paediatric Gastroenterology and Metabolic Diseases The aim of the study was to evaluate the concentration of nitrozamines in the gastric
juice and urine in children with chronic gastritis (CG). Methods: The
study was performed into two groups of children: I consisted of 30
children, aged 6-18 with CG and H.p. infection, II consisted of 30 children
with recurrent abdominal pain and without changes in gastroscopy. The
concentration of nitrozamines in gastric juice and urine tested by means of
gas chromatography-Merck model tests in children with CG was examined
before and after eradication treatment. In children without pathological
changes the examination was performed once only. Results:
In group I after treatment one found the statistically marked increase of
nitrozamines concentration in the gastric juice (1.031mg/l). It was particularly
higher in boys (1.499mg/l) in comparison to both values obtained before
treatment (0.074mg/l) and with the control group (0.063mg/l), and the group
of girls (0.924mg/l). One also observed a 10 fold excretion of nitrozamines
in urine after treatment (0.602mg/l) in comparison to the pre-treatment
values and the results obtained in the control group (0.029mg/l). After
treatment the markedly higher excretion of nitrozamines (0.755mg/l) in
urine was found in older children and it was much higher in boys
(0.892mg/l). Conclusions: It was found that nitrozamine concentrations in gastric juice and
urine in children with CG were closed to the values obtained in the control
group. After treatment, particularly in boys, one can observe markedly
significant increase on nitrozamine concentration both in gastric juice and
urine. Taking into consideration the possibility of a negative influence of
nitrozamine on gastric mucosa condition, one should recommend the H2
blockers treatment with particular caution.
Karol Marcinkowski University of Medical Sciences, Poznań, Poland