0361
THE INFLUENCE OF TREATMENT
WITH 5ASA AND/OR ITS DERIVATIVES ON OXIDANTIVE PROCESSES IN CHILDREN WITH
INFLAMMATORY BOWEL DISEASES Hanna Krauss, Iwona
Ignyś, Waldemar Malewski, Marian Krawczyński, Wojciech Cichy Department of
Paediatric Gastroenterology and Metabolic Diseases The aim of the study was
evaluate: 1. the exponents of proxidiantive mechanisms in the course
of inflammatory bowel disease, 2. if taking the nonhomogenous etiology of some diseases,
into consideration there are any differences in their activity, 3. if the application of treatment leading to clinical
remission is connected with the changes of the examined mechanisms. The
study was performed in a group of 35 children aged 8-17 with inflammatory
bowel diseases (IBD), which divided into three subgroups: I.
With ulcerative colitis II.
Crohn' disease III.
Nonspecific colitis The obtained results
were compared with 15 children's control group. The diagnosis was made on
the basis of care history, clinical evaluation of morphological picture in
colonoscopy and/or rectoscopy connected with histological evaluation of
colon mucosa. The
level of malonyldialdehyde in blood was marked acc. to Okhawa's method, the
level of hydrogen peroxide- by means of Frew's method before, 3 and 6 month
after treatment. The increase of prooxidantive processes was stated,
particularly in the group of IBD children. The applied treatment decreased
but not normalized the exponents of prooxidantive processes in children
with IBD.
Karol Marcinkowski University of Medical Sciences, Poznań, Poland