0362
THE INFLUENCE OF
TREATMENT WITH 5ASA AND/OR ITS DERIVATIVES ON ANTIOXIDANTIVE ENZYMATIC
ACTIVITY IN CHILDREN WITH INFLAMMATORY BOWEL DISEASES Hanna
Krauss, Iwona Ignyś, Waldemar Malewski, Wojciech Cichy, Department
of Paediatric Gastroenterology and Metabolic Diseases The
aim of the study was evaluate: 1.
The
exponents of antixidiantive mechanisms in the course of inflammatory bowel
disease, 2.
If
taking the nonhomogenous etiology of some diseases, into consideration
there are any differences in their activity and 3.
If
the application of treatment leading to clinical remission is connected
with the changes of the examined mechanisms. The study was performed in a
group of 35 children aged 8-17 with inflammatory bowel diseases (IBD),
which divided into three subgroups: I.
With ulcerative colitis; II. Crohn'
disease; III. Nonspecific
colitis. The
obtained results were compared with 15 children's control group. The
diagnosis was made on the basis of care history, clinical evaluation of
morphological picture in colonoscopy and/or rectoscopy connected with
histological evaluation of colon mucosa. Endoscopic and laboratory
examinations were performed in the time of the diagnosis (stage I), 3
(stage II) and 6 (stage III) month after starting the treatment. The
following parameters were examined in every patient: the activity of sodium
dismuthase (Misra-Fridovich' method), catalase (Beer's method), and
glutathione peroxidase (Little's, O'Brien's method). It was proven that
domination of prooxidantive processes and significant decrease of enzymatic
proteins' activity may constitute a potential mechanism of tissue damage in
gastrointestinal inflammatory conditions and at the same time suggests the
possibility of applying new antioxidantive therapy.
Marian Krawczyński
Karol Marcinkowski University of Medical Sciences, Poznań, Poland