Serum IgG Antibody to Pertussis-Specific in 0-5 Year- Old Children and Pregnant Women in China

Wang JM, Li J, Yuan L, Yu SJ, Shen XZH, Wang JF, He QSH, Yang YH

Laboratory of Microbiology and Immunology, Pediatric Research Institute, Beijing Children’ Hospital, Capital University of Medical Science, Beijing, China

Purpose: To determinate booster immunization at intervals throughout life by measured the serum IgG antibodies to pertussis-specific.

Methods and Materials: A total of 458 health individuals were enrolled and categorized into nine groups according to age. 458 sera were measured for IgG antibodies concentrations by ELISA.

Results: Median pertussis IgG antibodies concentrations were at the lower level in less than 6 months and 12 to 15 years old children which there were significant difference compared with the other seven groups (p<0.05). Meanwhile, that in 1-2 year-old group was at the highest level. An excellent correlation about IgG pertussis antibody concentrations was demonstrated of 54 paired serum specimens collected from pregnant women veins blood and umbilical cord blood(r=0.64 p<0.01).

Conclusions: It is necessary to booster vaccination in older children and pregnant women.

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