STUDY OF THE LEVEL OF IV COLLAGEN, PROLIDASE AND HYALINE ACID OF CHILDREN WITH NEPHRITIC SYNDROME

Chen D-P, Wang Z

Department of pediatrics, the Second Hospital, West China Medical Center, Sichuan University, Chengdu, China

Objective: To investigate the metabolism of IV collagen in the extra-glomerular matrix of the children with different kinds of nephrotic syndrome by test the levels of IV collagen, prolidase and hyaline acid of children with different kinds of nephrotic syndrome.

Methods: 77 children with nephrotic syndrome who were in our hospital during November 1998 to November 1999 were analyzed, 15 normal children were chosen as the control.

Results: The level of IV collagen increased and the level of prolidase decreased apparently in first treated children with nephritic nephrotic syndrome and secondary nephrotic syndrome compared with simple nephrotic syndrome and control. In re-treated children with nephritic and secondary nephrotic syndrome, the level of IV collagen increased and the level of prolidase decreased apparently in the children whose disease-processes were longer than two years compared with those whose disease-processes were less than two years. The level of IV collagen decreased and the level of prolidase increased after treated with hormone in first treated children with every kind of nephrotic syndrome. The levels of hyaline acid almost have no difference among children with different kinds of nephrotic syndrome and the control.

Conclusion: It can be seen that the metabolism of the IV collagen is abnormal. It may cause the unusual deposition of IV collagen and lead to the hyperplasia and fibrosis of extra-glomerular matrix of the children with nephritic and secondary nephrotic syndrome. The usage of hormone may hold back the unusual deposition of IV collagen in the extra-glomerular matrix. The level of hyaline acid has little effect in monitoring the hyperplasia and fibrosis of extra-glomerular matrix.

0371